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However, in contrast to these findings, a more recent large-scale randomized trial found no differences in the number of chronic obstructive pulmonary disease exacerbations per year or the yearly rate of decline in the forced expiratory volume in one second when 600 mg of N -acetylcysteine was taken orally once daily (63)
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This nonrandom distribution of cases with relatively high (or low) charges in specific MS-LTC-DRGs has the potential to inappropriately distort the measure of average charges
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